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Deca-durabolin history and overview deca-durabolin is the brand and trade name for the anabolic steroid nandrolonedecanoate, also called DDC, or decanoate. nandrolone decanoate is an anabolic agent approved for use by the US Food and Drug Administration (FDA) from 2001 to 2004 [ 1 ]. It is sold in tablet and capsule forms in the US and in many European countries and in many developing countries. It is available in oral, topical, and injectable form as well as depot injection solutions [ 2 ]. nandrolone decanoate contains the anabolic steroid norandrosterone. It binds to androgen receptors in prostate, uterus, adrenal, and testes; the effects of nandrolone decanoate extend to the entire male reproductive system; androgen receptor signaling is reduced in several species that lack endogenous anabolic steroids [ 3 ]. However, few studies have examined the potential androgenic and antiandrogenic effects of nandrolone decanoate in vivo and under in vitro conditions. In some cases it has been reported to potentiate the effects of estrogens at the pituitary level, whereas aspartate dehydrogenase (ADH), catabolism of testosterone and cortisol and subsequent conversion of these into a testosterone-like metabolite were not investigated [ 4 ]. However, in some studies nandrolone decanoate has been shown to have antiandrogenic properties at the prostate level when measured by prostate volume/Fo 2 measurements [ 5 – 7 ]. nandrolone decanoate is also used as a doping agent in sport and has been found to be an effective means of performance enhancement in competitive sports [ 8 ]. Nevertheless, as we will discuss below, nandrolone decanoate has anabolic effects to a lesser extent than other anabolic steroids and its presence in vivo may have important ramifications for other athletes. It is important to note, however, that studies examining nandrolone decanoate in vivo have not addressed effects on anabolic steroids. It is also interesting to note that although nandrolone decanoate, like other anabolic steroids is a potent anabolic agent, very little data have examined the potential for nandrolone decanoate to exert effects on anabolic steroids in vivo. As such, more research is needed on these issues and research will be necessary to establish the potential and effects of nandrolone decanoate on sport performance. Because the human body is anaerobic and anabolic steroids are commonly administered orally, the question will arise as to whether nandrol Similar articles: